Thanks to an innovative “warehouse” injection approach from a team at the Massachusetts Institute of Technology, long -term shots can become less painful. Including injecting small crystals hanging drugs suspended inside the solvents, the team can provide insomnia, less injections, and much less pain in general.
Description of the approach to a study in Nature chemical engineeringThe team says the method can work with contraceptive and other drugs that you take constantly over time.
“We have shown that we can have a great and sustainable delivery, most likely for several months and even years through a small needle,” said Giovanni Traversu, author of the Great Study and Professor of Mechanical Engineering at the Massachusetts Institute of Technology. press release.
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Delivery of drugs in slow and fixed shots
The warehouse injection is a type of shot that slowly release the drug over time. While the injection of other warehouses for sclerosis was developed in the deposit of the drug under the skin, the polymers that are added to these shots to allow them to sclerosis in addition to the largest part of them, which includes about 23 to 98 percent of their total weight. This requires them to inject them through the most difficult needy needles.
To develop a better alternative, the MIT team created a shot that can be delivered with a needy needle and still lasts for at least three months. By working with the medication of the contraceptive method, it turns into hanging crystals in a solvent, the snapshot can unite in drug deposits under the skin without the need for large amounts of polymers, which allows it to injection through thinner and more tolerance needles.
“The Massachusetts Institute of Massachusetts Institute for Massachusetts said
Not only that; This approach can also provide patients with more drug delivery options for other drugs that are given over time, including long -term drugs for HIV and tuberculosis.
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Development of drug delivery options
According to the team, the trick to the snapshot was a mixture of crystalline load for the attornexter and benzil benzil. By adding small crystals of this load with this solvent, the team created a shot that could gather in solid drug deposits after injection without large additives of polymers.
“The solvent is very important because it allows you to inject liquid through a small needle, but once the crystals are gathered in the drug warehouse,” Travorso said in the statement.
By adjusting the density of deposits with only a small addition of polymers (no more than 1.6 percent of the total weight of the bullets), the researchers found that they can control the rate of release of the drug throughout the body, and still without the need for a thicker needle.
“This indicates the connection of our system, which can be designed to accommodate a wide range of treated needs as well as doses systems specifically designed for other therapeutic applications,” said Sangion Park, the author of another major study and student of the Massachusetts Institute of Technology.
Although the approach has not been tested in humans, studies in mice show that the deposit deposits are committed for at least three months under the skin. At this point, about 85 percent of the drug still sit in warehouses – a quantity indicating that these deposits “can continue for more than a year,” Park said in the statement.
Additional animal studies are already conducted to determine whether the method is suitable for human test, whether it is a prevention method or other long -lasting drugs.
“Is it contraceptives? Is it the other? These are some of the things that we started looking at as part of the following steps towards translation into humans,” added Traffersu in the release.
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Article sources
Our book is in DiscoverMagazine.com Use studies reviewed by peers and high -quality sources of our articles, and review our editors for scientific accuracy and editorial standards. Review the sources used below for this article:
Sam Walters is a journalist covering archeology, excavation science, environment and development to discover, along with a variety of other topics. Before joining the Discover team as an assistant editor in 2022, Sam studied the press at Northwestern University in Ivston, Illinois.
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